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A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner ApoE-ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), linked to increased amyloid-β (Aβ) deposition in the brain. In AD mouse models, microglial expression of apoE3 reduces amyloid plaque burden through enhanced ...
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